There is a problem with both Moneypenny and Q.
The problem with Moneypenny is she's the secretary/assistant to M except (the current incarnation) James Bond doesn't go anywhere NEAR MI6 or any place where he'd NEED to encounter a secretary. He's completely off the radar. That said, there was a administrive assistant (Manning?) in Quantum of Solace and that could EASILY have been Moneypenny. So it's not impossible by any means.
The problem with Q is more... problematic, I suppose. Q is completely redundant now. Back when Connery and Moore were Bond, he'd be given this CRAZY gadget like a camera that's also a PHONE (I know, crazy right?!) and Q would explain how it works. The problem is that all those wacky gadgets... we actually have those bastards now. Q's redundant because - this is what the scene would be like:
Q: Ah, Bond. So glad you could make it an hour late.
Bond: Only an hour? I've beaten my own record. You should be proud.
Q: And you shouldn't take me for granted. One of these days, you'll be in need of my remote controlled appliances, and you won't have it because you couldn't be bothered to be punctual. Next time, no matter what I give you, I should stick a clock in it.
*looks at a small handheld device*
Bond: Is this for me, Q?
Q: Yes, Bond. Now be very careful. It's a prototype. It's a camera that also has a global satellite positioning coordinate in it.
Bond: ... And?
Q: You can also write and send messages to anyone meaning you don't actually have to speak to them. Should come in handy when stealth is needed!
Bond: Keep going.
Q: And, ah, it has a schedule organiser built in and oh, it can connect to our vast computer datanet at a transfer speed of 5 megabytes per second.
Bond: What else?
Q: It can contain up to 3 gigabytes of photos and music.
Bond: ...
Q: It's also a phone.
Bond: This is an iPhone. I have one.
Q: But if you turn it on it's side...
Bond: The display changes, yes, I know. I know how to use this. Everyone does. It's a mobile phone.
Q: ... It has a clock in it.
Die Another Day tried to keep Q (or rather R) relevant by making him John Cleese (awesome) and giving him LUDICROUS gadgets like a ****ing invisible car. An invisible car is far to sci-fi for Bond and also, ****ing stupid. What's a key sequence of Bond? The car chase. What's a stupid thing to do? Make the car INVISIBLE so you CAN'T SEE THE CAR CHASE. That's like setting all the action fights in a pitch-black environment.
The truth is, Bond STILL has his awesome gadgets. In Casino Royale he had the defibrillator thing in the glove box, and, as I've said he has a mobile phone. Mobile phones are INCREDIBLE TECH. Seriously. Kirk's communicator in Star Trek is obsolete by today's standards. Hell, some MILITARY GRADE communications equipment is less effective than a mobile phone (honestly - in Afghanistan British troops used their mobile phones instead of the military radio because it was more reliable). In Quantum of Solace you see surface computers and an incredible camera (it's also a phone, I bet) that can create composites of the face of person from a single action. The problem is that these things are so within our current level of technology that the audience knows how it works, Bond knows how it works, and the whole "Q explains what kick-*** gadgets Bond has" scene is now completely redundant. So Q just isn't necessary anymore, because if you DO give Bond gadgets that need explanation he goes into the realm of science-fiction and because of our current technological development, it just becomes ridiculous and especially so in the current Craig-Bond which is trying to be less and less far-fetched. Brosnan-Bond managed to keep the tradition going for Goldeneye, but it was less successful on each subsequent film he made up to Die Another Day which has James Bond driving an invisible car while fighting a man in a suit of cybernetic armour shooting a gigantic laser from a low orbit.
So Q... needs a bit of a change. Making him a techie who fixes or keeps things going is a possibility. He just needs to completely change from his previous "expository dump" tool that he was.
