Think about it in Watchmen terms...
*** Watchmen spoilers follow ***
The traitor has neutrialized the God-like figure (Thor in U2; Doc Manhattan in Watchmen); disgraced the warrior/soldier (Cap in U2; Comedian in Watchmen); alienated the insecure guy who relies on his costume and inventions for his strength (Pym in U2; Nite Owl in Watchmen)...
Okay, so they're not one-to-one correspondances, but the resonance is there...
And the bottom line is: who is the Ozymandias/Veidt-like figure with all the money, brains, and resources to pull this off? Who has the well-intentioned but potentially megalomaniacal Master Plan?
If we see a faked attempt on Tony's life during the wedding, resulting in the death of his lady-companion, during the next issue, it will just seal the deal, in my opinion.