speaking of punching in the face, I just read Wolverine vs Spider-Man (from 1987). In it Spidey and Wolverine are tracking a KGB operative through East Berlin. Towards the end Spidey and Wolverine get into a fight and Spidey realizes that because of Wolverine's adamantium skull, he has to punch Wolverine as hard as he can to do any damage at all. During the fight, the KGB operative they're tracking sneaks up on Spider-Man, his spider- sense goes off and he reacts and turns and punches her in the face full strength, thinking it's Wolverine. And he kills her!
Spider-Man killed a woman by punching her in the face!