The issue starts right where FNSM #4 ends in the Avengers Tower where the female creatures made of spiders, that had eaten Peters corps, just broke through the wall and is escaping by jumping to rooftop to rooftop. Spider-Man is following her/it whatever, and is catching up to her. The creature starts to talk and Spider-Man engage in a fight with it. During the fight the Stingers from his arms shows up again and the creature explains that even that spiders don't have stingers yet they will have in the future after evolving. She also explains that she is here because when Spider-Man was brought back to life by The Great Weaver (the big spider we saw in an earlier issue probably)another demi-cosmic entity was upset since it was Peters time to die and so sent this creature back with him. She is Spider-Mans opposite. She exist because he exists.
She jumps off the rooftop and into to sewers (after have transformed into many small spiders). Spider-Man doesn't follow her.
Back at the Tower everybody more or less blames Spider-Man for the recent action at Avengers Tower (even thou Tony say they don't) and it is proposed that Peter stay put until they know exactly whats going on.
Peter is resting in bed when Logan knocks on the door too see how he is doing. He tells Peter that there is something off with him, he doesn't smell the same. Something has changed.
MJ comes in and talks to Peter about what happened at the hospital. Peter says he doesn't remember anything after being knocked out by Morlun. He wants to know why she wants to know and she tells him that it's not important and they will talk about it some other day (a picture of Peter in his "monster" form that he was in when he attacked Morlun in the hospital is showed in the background).
Peter goes to see Doc Strange to ask him about the recent things that has happened in his life. Strange looks into his magic ball and tells Peter that he sees him in the middle of and cosmic web but he is not sure if he is the spider or the meal. Or both. He also tells him that his return has caused an uproar in the netherworlds and there will be a strong corrective response. Spider tells him that he thinks he already met her. He leaves.
A while later Peter sits out on the terrass and May comes out. He starts complaining about why just he was given a second chance and May comforts him saying that she got a feeling that fath has great thing in store for him.
The view zooms in to a church where on the inside of its tower a webbing and cocoon, similair to that Peter was in when he was resurrected, hangs. End of issue.