Should be interesting, though, I really hope they do something about that silly dome. I hate that thing. Also, there should be a connection to the one in the movie and the one that is to be a real villain. It would be silly otherwise. The new villain could just say he got the idea from the movie and that'll suit me fine. They just need to make a vague connection.
Also, Silvermane, in my opinion, belongs better in the pages of Ultimate X-Men now. He was referenced there and now that the reasons he was, Sinister and Gambit, are in full force, it seems only right to have him get involved with mutants. I was thinking along the lines of Horseman of Apocolypse for Silvermane...