Really? I don't seem to recall crazy stuff happening in Manhattan.
The three things that come to mind are the Triskelion getting blown up (think of how things were shut down with the World Trade Center went down and compare to the lack of references in the other books), the HUGE invasion of Chitauri all over the US, and the equally huge invasion of Norse gods (more concentrated in NYC I believe).
But I totally agree with you about the ripple effect of things like this. Attention to those details is what should have set the Ultimate books apart from the mainstream books. I think that kind of attention to detail tends to be viewed as a burden when it should have the complete opposite effect; it should open up huge and amazing opportunities for storytelling. How should the destruction of those tax havens affected just Tony Stark?!