Here's the way I see it:
The Simpsons are like Stan Lee. Love 'em or hate 'em....they're the foundation. Legends. Yeah they've been kinda crazy and slacking as of late....but ya can't really say anything bad about them.
Family Guy is like Brian K Vaugh. He's good. Real good. He delivers consistently each time. But ya might not like everythinghe does. So you might like the Chicken Fight bit...but ya didn't even chuckle during the Little Shop of Horrors spoof.
Meanwhile you got other primetime/late night cartoons like Sealab, Harvey Birdman, Venture Bros. These guys are the Mark Millars of toonage. They're like, "Yeah....I know I'm the man. I'm bringing ya the brand new hotness!!! But I gotta hear YOU say it. So go on....say it. I dare ya not to. Fine ya won't say I'm the man? Well I'm gonna shove topnotch product down your throat until you're choking on it. And the only way to clear that fat gullet of yours is to say I'm the man. So go on......say it."
Take it how you will..........