Okay, I will do my best:
Issue starts with DD talking about his super senses were both a blessing and a curse as a kid, his sense of hearing and smell would overload him before his training with Stick allowed him to block that background noise and smells, but his super seneses can still be a weakness as well as a strength. Matt talks about how he has been off his game because Lilly smells like Karen, but he is on to her and realizes she is part of the cabal of enemeis working against him, DD realizes this when he heard that Tombstone was working for a woman and dedeuced that woman was Lilly.
So DD shadows Tombstone for a while comes upon Tombstone collecting the "kidnapped" Lilly and driving her a meeting spot with Matador and some gangsters. Lilly pretends to be innocent hostage, but Matt can see through her. Instead of following Lilly's script DD sneaks up, takes out the gangsters and whacks Tombstone from behind. When Lilly tries to say something, DD slaps her. Matador and Tombstone attack DD, DD uses his superior speed and agility to avoid Matador, but Tombstone is able to get some licks in, however DD starting using Tombstone's speed and stength against him, tricking him into hitting his hand against a wall. DD also tricks Matador into slashing Tombstone with his sword, jumping out of the way of Matador's strike at the last second. Matt jumps away and Tombstone pulls out a gun. Tombstone heads to where Matt landed preparing to shoot him. However DD has grabbed a hammer and knocks Tombstone out with it.
Then Matador grabs Lilly and threatens to kill her. Lilly seems to be geniunely scared, but DD still thinks she is faking. Matador starts to cut and draw blood on Lilly's neck. However then the Matador freaks out and says he can't go through with the plan to kill her, because he is in love with her. Lilly calls Matador a idiot and rejects him. Then DD knocks him out.
Lilly tries to play innocent victim again, but Matt sees through it, stating that she had her father killed to get control of his criminal empire and demands the truth. Matt tells Lilly that they planned on killing her all along, because she remineded him of Karen and the criminals wanted to kill Lilly right in front of him so he would relive Karen's death.
Lilly decides to reveal everything she knows so DD would capture those who betrayed her. It is revealed that the mastermind gave Lilly a bottle of perfumed laced with pheromones that would allow her to influence men (which is why she smelled like Karen). We don't see the rest of conversation regarding the details Lilly reveals about DD's tormentor, but we do see DD's reaction: he feels like someone has stabbed him in the back.
That's the issue.
This is why I think either Mr. Fear (Larry Cranston) or Purple Man are behind this, both have acess mind altering pheromones, Purple Man's powers come pheromones and Alan ***an was distill a pheromone from the fear gas that would make him (almost) irresistible to women, want to bet his uncle could do the same thing and have to work on men. Both have a grudge against DD and have the desire to inflict maximin emotional damage on DD. Killgrave is a sadist psychopath, who hates super heroes, especially ones who have defeat him in the past, while Cranston has dedicated his life towards getting revenge on Matt. Both would be willing to hurt matt and have the means and motive to doso. Unless Brubaker throws a curve ball, that's who I would bet on.
). Plus this interview from brubaker states that Brubaker will use and likely revamp other "lame" DD villains:
