It's going to be difficult to write arcs for this title using "ultimized" versions of 616 villains, since UXM seems to want to stay clear of all the time travel/dimension hopping/intergalactic-like stuff because that is a HUGE part of 616 X-Men. We saw what Vaughan did to ultimize Apocalypse, but can the same be done for all the rest of the characters that fall under these banners (Bishop, Cable, Strife, The Sh'iar, etc.). I mean, that stuff was as big a part - if not bigger - than the stuff relating to human/mutant co-existence. Sure, some of these characters could get a pretty good treatment without tying them into those categories..but all of them?
Saying that, we still have no idea whether The Phoenix will be connected to any of those, and that would change the direction of the title significantly. Hope not.